Using EHR to Detect Alzheimer’s and Increase Engagement
Clinical Trial Knowledge Hub
CTRL Pilot
Using EHR to Detect Alzheimer’s and
Increase Engagement
Research Focus
Can electronic health records (EHRs) be used to identify patients with undetected dementia or those at elevated one-year risk? Can a direct text message connect these patients to follow-up care and clinical trial opportunities?
Study Term
2024 – 2026
Status
In progress
Pilot Description
Researchers developed a machine-learning algorithm, the Passive Digital Marker (PDM), that analyzes EHRs to predict with 80% accuracy which patients are likely to have or develop Alzheimer’s disease or related dementias within one to three years. A trial at 12 primary care clinics in the Indiana University Health system is testing whether the PDM can be used in primary care to identify patients with undetected dementia or those likely to develop it within one year. Researchers will also measure if a direct text messaging intervention can increase patient engagement in research and follow-up care with a Brain Health Navigator (BHN), a registered nurse trained to assess cognitive issues and guide physicians and patients through subsequent diagnostic steps.
Participant Input
To strengthen the effectiveness of text message outreach, researchers partnered with experts in user-centered design at the Indiana Clinical and Translational Sciences Institute. Two in-person focus groups were held with 26 people aged 65 and older, recruited from primary care clinics. Participants were asked to suggest improvements to prewritten scripts, providing feedback that informed the final messaging.
Key Lessons
Trust matters
Older adults are willing to receive texts from a trusted provider but are skeptical of unbranded messages
Help wanted
Patients strongly endorsed the BHN concept and expressed a desire for clear information about the program
Easy connections
Patients want multiple options for connecting with a BHN and the ability to opt out of messaging if they prefer
Healthy interest
Patients are motivated by concerns about dementia and expressed strong interest in receiving support to navigate care and take proactive steps for their health
