Feasibility of Community-Based Plasma Biomarker Collection
Clinical Trial Knowledge Hub

CTRL Pilot
Feasibility of Community-Based
Plasma Biomarker Collection
Research Focus
Can community-based plasma biomarker collection identify patients eligible for early-stage Alzheimer’s trials?
Study Term
2022-2024
Status
Completed
Pilot Description

Participants in an online memory concerns registry were asked to provide remote electronic consent to blood collection. Participants were 50 or older, did not have a dementia diagnosis and lived near a specific lab or clinical trial site.
In the primary aim, consented participants were asked to provide blood samples at a community lab such as Quest Diagnostics. Primary outcomes included completion of electronic consent and successful blood draws, return of biomarker data for analysis, and completion of telephone-based eligibility communications.
In a second study arm, researchers evaluated whether usable blood samples can be successfully collected at community events on the same day people agreed to a blood draw and then assessed for trial eligibility using a similar approach.
Participant Input
Researchers established a support team to respond to participant inquiries. The support team also collected feedback from participants about their study experiences, particularly related to blood draws and receipt of their plasma biomarker eligibility results.

Key Lessons

Interest exceeded expectations
Nearly 40% of invitees provided electronic consent, and 70% of them provided usable blood samples

Broad reach
Participation rates were consistent across demographic groups

Local draw
It is feasible to increase participation through same-day blood draws at community events
Learn More
🔎 Published Research
“The AlzMatch Pilot Study – Feasibility of Remote Blood Collection of Plasma Biomarkers for Preclinical Alzheimer’s Disease Trials.” The Journal of Prevention of Alzheimer’s (2024).
📰 In the News
“How a Gift Card Could Help Speed Up Alzheimer’s Clinical Research”
Lead Researchers

Co-chair, Clinical Trial Recruitment Lab
Director, USC Alzheimer’s Therapeutic
Research Institute (ATRI)


